8254. Ronidazole

Nomenclature

CAS number: 7681-76-7
1-Methyl-5-nitroimidazole-2-methanol carbamate (ester); carbamic acid (1-methyl-5-nitroimidazol-2-yl)methyl ester; 1-methyl-2-[(carbamoyloxy)methyl]-5-nitroimidazole; (1-methyl-5-nitroimidazole-2-yl)methyl carbamate; MCMN; Ridzol (Merck & Co.).
C6H8N4O4; mol wt 200.15.
C 36.01%, H 4.03%, N 27.99%, O 31.97%.

Description and references

Prepn and antiprotozoal activity: NL 6609552; NL 6609553 (both 1967 to Merck & Co.), C.A. 67, 54123u, 11487y (1967); Verdi; Kollonitsch, US 3450710; US 3459764 (both 1969 to Merck & Co.).

Chemical structure

Properties

Pale yellow crystals, mp 167-169°. Soly in water (at pH 6.5) ≈2.9 mg/ml at room temp. More sol in acid solns. Unstable in alkaline solns. pKa 1.2. Freely sol in acetone. Sol in methanol, ethanol, chloroform and ethyl acetate.

Therapeutic Category (Veterinary)

Antimicrobial.