8255. Ronifibrate

Nomenclature

CAS number: 42597-57-9
3-Pyridinecarboxylic acid 3-[2-(4-chlorophenoxy)-2-methyl-1-oxopropoxy]propyl ester; 3-(nicotinoyloxy)propyl p-chlorophenoxyisobutyrate; 3-[α-(p-chlorophenoxy)isobutyryloxy]propyl nicotinate; I-612; Cloprane (Luitpold).
C19H20ClNO5; mol wt 377.82.
C 60.40%, H 5.34%, Cl 9.38%, N 3.71%, O 21.17%.

Description and references

Diester of clofibric and nicotinic acids, q.q.v. Prepn: Y. Hirata et al., JP Kokai 73 40777 (1973 to Yamanouchi), C.A. 79, 66180w (1973); H. Shindo et al., JP Kokai 74 30377 (1974 to Kowa Pharm.), C.A. 81, 135984s (1974). Clinical trial in hyperdyslipidemia: A. Bucalossi et al., Clin. Ter. 89, 127 (1979). Efficacy and tolerability: G. Buzzelli et al., ibid. 251.

Chemical structure

Properties

LD50 orally in mice: 4.08 g/kg (Bucalossi).

Therapeutic Category

Antilipemic.

Keywords

Antilipemic; Fibrates