8907. Sulfaethidole

Nomenclature

CAS number: 94-19-9
4-Amino-N-(5-ethyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide; N1-(5-ethyl-1,3,4-thiadiazol-2-yl)sulfanilamide; 5-ethyl-2-sulfanilamido-1,3,4-thiadiazole; 2-(p-aminobenzenesulfonamido)-5-ethylthiadiazole; sulfaethylthiadiazole; VK-55; Sul-Spantab (SK & F).
C10H12N4O2S2; mol wt 284.36.
C 42.24%, H 4.25%, N 19.70%, O 11.25%, S 22.55%.

Description and references

The commercial prepn (Schering AG) is described in P.B. reports, no. 245, p 5, and no. 1361, p 73. Prepn: Wojahn, Wuckel, Arch. Pharm. 284, 53 (1951).

Chemical structure

Properties

Crystals, mp 185.5-186.0°. One gram dissolves in 4000 ml water, in 40 g methanol, in 30 g ethanol, in 10 g acetone, in 1350 g ether, in 2800 g chloroform, in 20,000 g benzene. Faintly acid to litmus.

Derivative

Sodium salt.

Properties

pH of 20% soln: 7.5.

Therapeutic Category

Antibacterial.

Therapeutic Category (Veterinary)

Antimicrobial.

Keywords

Antibacterial (Synthetic); Sulfonamides