9104. Teclothiazide

Nomenclature

CAS number: 4267-05-4
6-Chloro-3,4-dihydro-3-trichloromethyl-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide; 6-chloro-3,4-dihydro-7-sulfamoyl-3-trichloromethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 3-trichloromethylhydrochlorothiazide; tetrachlormethiazide.
C8H7Cl4N3O4S2; mol wt 415.10.
C 23.15%, H 1.70%, Cl 34.16%, N 10.12%, O 15.42%, S 15.45%.

Description and references

Prepn: Close et al., J. Am. Chem. Soc. 82, 1132 (1960); Novello et al., J. Org. Chem. 25, 970 (1960). Pharmacology and toxicology: M. Auclair et al., Therapie 18, 131, 137 (1963).

Chemical structure

Properties

Crystals, mp 300-303° (Close); mp 287° (Novello).

Derivative

Potassium salt.

Nomenclature

CAS number: 5306-80-9
PS-207; K-33; Depleil (Promedica).
C8H6Cl4KN3O4S2; mol wt 453.19.
C 21.20%, H 1.33%, Cl 31.29%, K 8.63%, N 9.27%, O 14.12%, S 14.15%.

Properties

LD50 i.p. in mice: 4.75 g/kg (Auclair).

Therapeutic Category

Diuretic.

Keywords

Antihypertensive; Thiazides and Analogs; Diuretic; Thiazides and Analogs