9105. Teclozan

Nomenclature

CAS number: 5560-78-1
N,N′-[1,4-Phenylenebis(methylene)]-bis[2,2-dichloro-N-(2-ethoxyethyl)acetamide]; N,N′-bis(ethoxyethyl)-N,N′-bis(dichloroacetyl)-1,4-xylylenediamine; N,N′-bis(dichloroacetyl)-N,N′-bis(2-ethoxyethyl)-1,4-bis(aminomethyl)benzene; teclosan; teclosine; teclozine; NSC-107433; Win-13146; Win-AM-13146; Falmonox (Winthrop).
C20H28Cl4N2O4; mol wt 502.26.
C 47.83%, H 5.62%, Cl 28.23%, N 5.58%, O 12.74%.

Description and references

Prepn: Surrey, Mayer, J. Med. Pharm. Chem. 3, 409 (1961). Amebicidal activity and toxicity: Berberian et al., Am. J. Trop. Med. Hyg. 10, 503 (1961).

Chemical structure

Properties

Crystals, mp 137.6-143.9°. LD50 orally in mice: >8000 mg/kg (Berberian).

Therapeutic Category

Antiamebic.

Keywords

Antiamebic