9108. Tedisamil

Nomenclature

CAS number: 90961-53-8
3′,7′-Bis(cyclopropylmethyl)spiro[cyclopentane-1,9′-[3,7]diazabicyclo[3.3.1]nonane].
C19H32N2; mol wt 288.47.
C 79.11%, H 11.18%, N 9.71%.

Description and references

Potassium channel blocking bradycardic agent. Prepn: U. Sch"on et al., DE 3234697; eidem, US 4550112 (1984, 1985 both to Kali-Chemie); and pharmacology: idem et al., J. Med. Chem. 41, 318 (1998). Suppression of the outward transient K+ current in rat myocytes: I. D. Dukes, M. Morad, Am. J. Physiol. 275, H1746 (1989). Toxicity in rats: E. Hayes et al., Pharmacol. Toxicol. 73, 257 (1993). Comparative clinical study in coronary artery disease: V. Mitrovic, et al., Clin. Cardiol. 21, 492 (1998). Clinical study in stable angina: K. M. Fox et al., Heart 83, 167 (2000). Review of pharmacology and clinical development: B. Freestone, G. Y. H. Lip, Expert Opin. Invest. Drugs 13, 151-160 (2004).

Chemical structure

Derivative

Dihydrochloride.

Nomenclature

CAS number: 132523-84-3
C19H32N2.2HCl; mol wt 361.39.
C 63.15%, H 9.48%, N 7.75%, Cl 19.62%.

Properties

White crystals, mp 195-197°. bp 230° (0.1 Torr). Sol in water.

Derivative

Sesquifumarate.

Nomenclature

CAS number: 150501-62-5
KC-8857; Pulzium (Solvay).
(C19H32N2)2.3C4H4O4; mol wt 925.16.
C 64.91%, H 8.28%, N 6.06%, O 20.75%.

Description and references

Prepn: U. Sch"on et al., US 5324732 (1994 to Kali-Chemie).

Properties

Crystals, mp 135.8-136.9°. Soly in water: 4.4g/100ml.

Therapeutic Category

Antiarrhythmic (class III).

Keywords

Bradycardic Agent; Antiarrhythmic; Potassium Channel Blocker