9167. Terlipressin

Nomenclature

CAS number: 14636-12-5
N-[N-(N-Glycylglycyl)glycyl]-8-l-lysinevasopressin; Nα-glycylglycylglycylvasopressin; 1-triglycyl-8-lysinevasopressin; Glypressin (Ferring).
C52H74N16O15S2; mol wt 1227.37.
C 50.89%, H 6.08%, N 18.26%, O 19.55%, S 5.22%.

Description and references

Analog of lypressin, q.v. Prepn: E. Kasafirek et al., Collect. Czech. Chem. Commun. 31, 4581 (1966); Z. Procházka et al., ibid. 43, 1285 (1978). Pharmacological studies: J. Kyncl et al., Eur. J. Pharmacol. 28, 294 (1974); P. O. B. Sj"oquist et al., Acta Pharmacol. Toxicol. 40, 369 (1977). Use in treatment of uterine bleeding: V. Pavlin et al., Br. J. Obstet. Gynaecol. 85, 801 (1978). Hemostatic effects in cirrhosis patients: C. V. Prowse et al., Eur. J. Clin. Invest. 10, 49 (1980). Conversion to lysine vasopressin in man: M. L. Forsling et al., J. Endocrinol. 85, 237 (1980). Uterine effects in first trimester of pregnancy: T. Laudanski, M. Aakerlund, Contraception 22, 199 (1980). Single-dose effects on renal potassium excretion in humans: H. Nadvornikova, O. Schueck, Int. J. Clin. Pharmacol. Ther. Toxicol. 20, 155 (1982).

Chemical structure

Derivative

Diacetate pentahydrate.

Nomenclature

Glycylpressin (Ferring).
C56H82N16O19S2.5H2O; mol wt 1437.55.
C 46.79%, H 6.45%, N 15.59%, O 26.71%, S 4.46%.

Properties

[α]D25 -82° (c = 0.2 in 1M acetic acid).

Therapeutic Category

Vasopressor (treatment of uterine and esophogeal bleeding).

Keywords

Antidiuretic