9168. Terofenamate

Nomenclature

CAS number: 29098-15-5
2-[(2,6-Dichloro-3-methylphenyl)amino]benzoic acid ethoxymethyl ester; N-(2,6-dichloro-m-tolyl)anthranilic acid ethoxymethyl ester; etoclofene.
C17H17Cl2NO3; mol wt 354.23.
C 57.64%, H 4.84%, Cl 20.02%, N 3.95%, O 13.55%.

Description and references

Anthranilic acid derivative. Prepn: GB 1199386; E. Manghisi, US 3642864 (1970, 1972 both to Lusofarmaco); A. Salembeni et al., Farmaco Ed. Sci. 30, 276 (1975). Biological properties: G. B. Fregnan et al., ibid. 353. Absorption, distribution, excretion: eidem, Boll. Chim. Farm. 114, 85 (1975). Pharmacological and toxicity studies: T. Chieli et al., ibid. 115, 41 (1976).

Chemical structure

Properties

Crystals from ethanol, mp 73-74°. LD50 in mice, rats (mg/kg): 918, 307 orally; 300, 274 i.p. (Chieli).

Therapeutic Category

Anti-inflammatory.