9688. Triflusal

Nomenclature

CAS number: 322-79-2
2-(Acetyloxy)-4-(trifluoromethyl)benzoic acid; α,α,α-trifluoro-2,4-cresotic acid acetate; acetyl-4-trifluoromethylsalicylic acid; UR-1501; Disgren (Uriach).
C10H7F3O4; mol wt 248.16.
C 48.40%, H 2.84%, F 22.97%, O 25.79%.

Description and references

Analog of aspirin, q.v.; inhibits platelet aggregation. Prepn of free acid: M. Hauptschein, US 3019253 (1962 to Pennsalt). Inhibition of platelet aggregation in man and rat: J. Garcia-Rafanell, J. Morell, Therapie 32, 337 (1977). Effect on blood coagulation: M. Rutllant et al., Curr. Ther. Res. 22, 510 (1977). Pharmacokinetics: V. Rimbau et al., Arch. Farmacol. Toxicol. 7, 11 (1981). Clinical studies: R. M. Masso et al., Curr. Ther. Res. 25, 791 (1979); E. Sala-Planell et al., Angiologia 33, 71 (1981).

Chemical structure

Properties

White cryst solid from petr ether/ether, mp 120-122° (upon slow heating); 110-112° (upon quick heating). Misc with ethanol. Practically insol in water.

Therapeutic Category

Antithrombotic.

Keywords

Antithrombotic