9699. Trimebutine

Nomenclature

CAS number: 39133-31-8
3,4,5-Trimethoxybenzoic acid 2-(dimethylamino)-2-phenylbutyl ester.
C22H29NO5; mol wt 387.47.
C 68.20%, H 7.54%, N 3.61%, O 20.65%.

Description and references

Opioid receptor agonist. Prepn by esterification: C. P. J. Roux, D. R. Torossian, FR 1344455 (1963 to Jouveinal), C.A. 60, 15777g (1964); see also: D. R. Torossian, G. G. Aubard, GB 1342547 (1974 to Jouveinal). HPLC determn in plasma: M. Lavit et al., Arzneim.-Forsch. 50, 640 (2000). Review of pharmacology and clinical experience: M. Delvaux, D. Wingate, J. Int. Med. Res. 25, 225-246 (1997).

Chemical structure

Properties

Crystals from ethanol, mp 78-80°C. Soluble in methylene chloride.

Derivative

Maleate.

Nomenclature

CAS number: 34140-59-5
TM-906; Cerekinon (Tanabe); Debridat (Pfizer); Digerent (Polifarma); Modulon (Pfizer); Polibutin (Juste); Spabucol (Lagap); Transacalm (Norgine).
C22H29NO5.C4H4O4; mol wt 503.54.
C 62.02%, H 6.61%, N 2.78%, O 28.60%.

Properties

Crystals from water, mp 105-106°.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic