9700. Trimecaine

Nomenclature

CAS number: 616-68-2
2-Diethylamino-2′,4′,6′-trimethylacetanilide; N-sym-trimethylphenyldiethylaminoacetamide; 2-diethylaminoacetyl-2′,4′,6′-trimethylanilide; S-203; Mesocaine; Mesidicaine; Mesokain.
C15H24N2O; mol wt 248.36.
C 72.54%, H 9.74%, N 11.28%, O 6.44%.

Description and references

Prepn: Lfgren, Lundqvist, US 2441498 (1948 to Astra); A. Borovansky et al., J. Am. Pharm. Assoc. 48, 402 (1959).

Chemical structure

Properties

Crystals, mp 44°. bp6 187°; bp0.6 154-155°. LD50 s.c. in mice: 295 mg/kg (Borovansky).

Derivative

Hydrochloride.
C15H24N2O.HCl; mol wt 284.82.
C 63.25%, H 8.85%, N 9.84%, O 5.62%, Cl 12.45%.

Properties

Crystals from acetone, mp 140°.

Therapeutic Category

Anesthetic.

Keywords

Anesthetic (Local)