9722. Trimipramine

Nomenclature

CAS number: 739-71-9
10,11-Dihydro-N,N,β-trimethyl-5H-dibenz[b,f]azepine-5-propanamine; 5-[3-(dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenz[b,f]azepine; 5-(3-dimethylamino-2-methylpropyl)iminodibenzyl; trimeprimine; trimeproprimine; RP-7162; Sapilent (EGYT).
C20H26N2; mol wt 294.43.
C 81.59%, H 8.90%, N 9.51%.

Description and references

Prepn: Jacob, Messer, Compt. Rend. 252, 2117 (1961). Toxicity studies: Okamoto, C.A. 72, 77299y (1970). Chemistry: Bever, Bredenstein, Dtsch. Apoth. Ztg. 113, 1562 (1973). Comprehensive description of the maleate: A. A. Al-Badr, Anal. Profiles Drug Subs. 12, 683-712 (1983).

Chemical structure

Properties

Crystals, mp 45°.

Derivative

Maleate.

Nomenclature

CAS number: 521-78-8
Stangyl (tabl) (Rhone-Poulenc); Surmontil (tabl) (Rhone-Poulenc).
C20H26N2.C4H4O4; mol wt 410.51.
C 70.22%, H 7.37%, N 6.82%, O 15.59%.

Properties

Crystals, mp 142°. Sol in chloroform; slightly sol in water, ethanol. Practically insol in ether.

Derivative

Methanesulfonate.

Nomenclature

Stangyl (amp) (Rhone-Poulenc); Surmontil (amp) (Rhone-Poulenc).

Therapeutic Category

Antidepressant.

Keywords

Antidepressant; Tricyclics