9941. Vecuronium Bromide

Nomenclature

CAS number: 50700-72-6
1-[(2β,3α,5α,16β,17β)-3,17-Bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl]-1-methylpiperidinium bromide; NC-45; Org-NC-45; Musculax (Nippon Organon); Norcuron (Organon).
C34H57BrN2O4; mol wt 637.73.
C 64.03%, H 9.01%, Br 12.53%, N 4.39%, O 10.04%.

Description and references

Aminosteroid, competitive neuromuscular blocker. Prepn: W. R. Buckett et al., J. Med. Chem. 16, 1116 (1973); I. C. Carlyle et al., EP 8824 (1980 to Akzo), C.A. 93, 155850 (1980). Series of articles on pharmacology, pharmacokinetics, pharmacodynamics, clinical studies: Br. J. Anaesth. 52, Suppl. 1, 1S-72S (1980). Clinical pharmacology: M. R. Fahey et al., Anesthesiology 55, 6 (1981). Comparison with pancuronium bromide, q.v.: S. L. Son et al., ibid. 12.

Chemical structure

Properties

Crystals, mp 227-229°. LD50 in mice: 0.061 mg/kg i.v. (Buckett).

Therapeutic Category

Neuromuscular blocking agent.

Therapeutic Category (Veterinary)

Neuromuscular blocking agent.

Keywords

Neuromuscular Blocking Agent; Nondepolarizing Agents