9942. Vedaprofen

Nomenclature

CAS number: 71109-09-6
4-Cyclohexyl-α-methyl-1-naphthaleneacetic acid; 2-(4-cyclohexyl-1-naphthyl)-propionic acid; CERM-10202; PM-150; Quadrisol (Intervet).
C19H22O2; mol wt 282.38.
C 80.81%, H 7.85%, O 11.33%.

Description and references

Propionic acid type non-steroidal anti-inflammatory drug (NSAID). Prepn: J. J. Godfroid, E. Steiner, BE 870553; eidem, US 4218473 (1979, 1980 both to CERM). Summary of field trials in dogs: J. G. H. Bergman, P. van Laar, Vet. Q. 18, S20 (1996). Pharmacodynamics and pharmacokinetics in horses: P. Lees et al., J. Vet. Pharmacol. Ther. 22, 96 (1999).

Chemical structure

Properties

Crystals from ethyl alcohol/water, mp 150°. LD50 orally in rat: 400 mg/kg (Godfroid).

Therapeutic Category (Veterinary)

Anti-inflammatory.