12-01784. Camylofine [Archived]

Nomenclature

CAS number: 54-30-8
α-[[2-(Diethylamino)ethyl]amino]benzeneacetic acid 3-methylbutyl ester; N-[2-(diethylamino)ethyl]-2-phenylglycine isopentyl ester; isoamyl α-[N-(β-diethylaminoethyl)amino]phenylacetate; isoamyl N-(β-diethylaminoethyl)-α-aminophenylacetate; α-[(β-diethylaminoethyl)amino]phenylacetic acid isoamyl ester; acamylophenine.
C19H32N2O2; mol wt 320.47.
C 71.21%, H 10.06%, N 8.74%, O 9.98%.

Description and references

Anticholinergic. Prepn: Schmeisser et al., DE 842206 (1952 to Asta), C.A. 47, 5445i (1953); GB 688331 (1953); Chielmetti, Farm. Sci. Tec. 7, 625 (1952), C.A. 47, 11161 (1953); Edwards et al., J. Pharm. Pharmacol. 12, 179 (1960).

Chemical structure

Properties

Pale yellow oil, bp1.5 174-178°, bp4 165-180°. Strongly alkaline reaction.

Derivative

Dihydrochloride.

Nomenclature

CAS number: 5892-41-1
Avacan (Asta).
C19H32N2O2.2HCl; mol wt 393.39.
C 58.01%, H 8.71%, N 7.12%, O 8.13%, Cl 18.02%.

Properties

Crystals, mp 174-178°, also reported as mp 172° and 173°. Soluble in water.

Therapeutic Category

Antispasmodic.

Keywords

Antispasmodic

Status

This monograph has been retired and is no longer subject to revision or update.