12-07232. Penicillin V Hydrabamine [Archived]

Nomenclature

CAS number: 6591-72-6
N,N′-Bis(dehydroabietyl)ethylenediamine bis(phenoxymethylpenicillin); hydrabamine phenoxymethyl penicillin; hydrabamine penicillin V.
C74H100N6O10S2; mol wt 1297.75.
C 68.49%, H 7.77%, N 6.48%, O 12.33%, S 4.94%.

Description and references

Semi-synthetic antibiotic. Prepn: DeRose, US 2812326 (1956 to Abbott).

Properties

Solubilities determined by Weiss et al., Antibiot. Chemother. 7, 374 (1957) in mg/ml at about 28°: Water 0.05; methanol 11.05; ethanol 5.8; isopropanol 1.75; isoamyl alcohol 6.85; cyclohexane 0.12; benzene 1.4; toluene 1.07; petr ether 0.06; isooctane 0.065; carbon tetrachloride 3.30; ethyl acetate 4.0; isoamyl acetate 4.9; acetone 10.2; methyl ethyl ketone 13.7; ether 0.095; ethylene chloride >20; dioxane 7.5.

Therapeutic Category

Antibacterial.

Keywords

Antibacterial (Antibiotics); β-Lactams; Penicillins

Status

This monograph has been retired and is no longer subject to revision or update.