12-09908. Tropenzile [Archived]

Nomenclature

CAS number: 53834-53-0
(3-endo, 6-exo)-α-Hydroxy-α-phenylbenzeneacetic acid 6-methoxy-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester; 6-methoxy-1αH,5αH-tropan-3α-ol benzilate; 6-methoxytropine benzilate; benzilic acid 6-methoxytropine ester.
C23H27NO4; mol wt 381.46.
C 72.42%, H 7.13%, N 3.67%, O 16.78%.

Description and references

Anticholinergic. Prepn: Stoll et al., Helv. Chim. Acta 38, 571 (1955); CH 325296 (1957 to Sandoz).

Chemical structure

Properties

Needles from benzene + petr ether, mp 99-101°.

Derivative

Hydrochloride.
C23H27NO4.HCl; mol wt 417.93.
C 66.10%, H 6.75%, N 3.35%, O 15.31%, Cl 8.48%.

Properties

mp 146-148°.

Therapeutic Category

Antispasmodic.

Status

This monograph has been retired and is no longer subject to revision or update.