13-00798. Arprinocid [Archived]

Nomenclature

CAS number: 55779-18-5
9-[(2-Chloro-6-fluorophenyl)methyl]-9H-purin-6-amine; 9-(2-chloro-6-fluorobenzyl)adenine; MK-302; Arpocox (Merck & Co.).
C12H9ClFN5; mol wt 277.68.
C 51.90%, H 3.27%, Cl 12.77%, F 6.84%, N 25.22%.

Description and references

Prepn: E. P. Lira et al., FR 2128600; eidem, US 3846426 (1972, 1974, both to Int. Minerals and Chem.); G. D. Hartman et al., J. Org. Chem. 43, 960 (1978). Determination in feed: D. W. Fink et al., J. Assoc. Off. Anal. Chem. 61, 1078 (1978); 62, 1 (1979). Evaluation of anticoccidial efficacy: P. Schindler et al., Poult. Sci. 58, 23 (1979); L. R. McDougald, J. K. Johnson, ibid. 72.

Chemical structure

Properties

Cryst from methanol/water, mp 245-246°.

Therapeutic Category (Veterinary)

Coccidiostat.

Status

This monograph has been retired and is no longer subject to revision or update.