Orphenadrine Hydrochloride Tablets
Action and use
Anticholinergic.
Definition
Orphenadrine Hydrochloride Tablets contain Orphenadrine Hydrochloride.
Content of orphenadrine hydrochloride, C18H23NO,HCl
92.5 to 107.5% of the stated amount.
Identification
Extract a quantity of the powdered tablets containing 0.15 g of Orphenadrine Hydrochloride with chloroform, filter and evaporate the filtrate to dryness. The residue complies with the following tests.
Assay
Weigh and powder 20 tablets. Dissolve a quantity of the powder containing 70 mg of Orphenadrine Hydrochloride as completely as possible in a mixture of 5 mL of water and 5 mL of 2m hydrochloric acid. Without delay extract with four 15 mL quantities of chloroform, filter the combined extracts and evaporate to about 20 mL. Carry out Method I for non-aqueous titration, Appendix VIII A, using 0.02m perchloric acid VS, adding 2 mL of mercury(II) acetate solution and determining the end point potentiometrically. Each mL of 0.02m perchloric acid VS is equivalent to 6.118 mg of C18H23NO,HCl.