2184. Chlorproguanil

Nomenclature

CAS number: 537-21-3
N-(3,4-Dichlorophenyl)-N′-(1-methylethyl)imidodicarbonimidic diamide; 1-(3,4-dichlorophenyl)-5-isopropylbiguanide; N1-3,4-dichlorophenyl-N5-isopropylbiguanide; N1-3,4-dichlorophenyl-N5-isopropyldiguanide; M-5943.
C11H15Cl2N5; mol wt 288.18.
C 45.85%, H 5.25%, Cl 24.60%, N 24.30%.

Description and references

Method of prepn: Crowther et al., J. Chem. Soc. 1951, 1780; Curd et al., US 2544827 (1951); Crowther et al., GB 667116 (1952) (both to ICI). Clinical trial with dapsone, q.v., in drug-resistant malaria: T. Mutabingwa et al., Lancet 358, 1218 (2001).

Chemical structure

Derivative

Hydrochloride.

Nomenclature

CAS number: 15537-76-5
Lapudrine (Zeneca).
C11H15Cl2N5.HCl; mol wt 324.64.
C 40.70%, H 4.97%, Cl 32.76%, N 21.57%.

Properties

Crystals, mp 246-247°. Soly in water: 1 g/100 ml. Solns may be boiled without dec.

Therapeutic Category

Antimalarial.

Keywords

Antimalarial