8991. Sulprostone

Nomenclature

CAS number: 60325-46-4
(5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3R)-3-hydroxy-4-phenoxy-1-butenyl]-5-oxocyclopentyl]-N-(methylsulfonyl)-5-heptenamide; CP-34089; SHB-286; ZK-57671; Nalador (Schering AG).
C23H31NO7S; mol wt 465.56.
C 59.34%, H 6.71%, N 3.01%, O 24.06%, S 6.89%.

Description and references

Analog of prostaglandin E2, q.v., with uterine stimulant activity. Prepn: J. Bindra, M. R. Johnson, DE 2355540 (1974 to Pfizer), C.A. 81, 49330u (1974); eidem, US 4024179 (1977 to Pfizer). Antifertility effects: H. Hess et al., Experientia 33, 1076 (1977). Influence on platelet function: R. C. Briel, T. H. Lippert, Adv. Prostaglandin Thromboxane Res. 6, 351 (1980). Biological action and half-life: eidem, Prostaglandins Med. 6, 1 (1981). Induction of abortion: K. Schmidt-Gollwitzer, Int. J. Fertil. 26, 86 (1981).

Chemical structure

Properties

Colorless oil.

Therapeutic Category

Abortifacient.

Keywords

Abortifacient/Interceptive; Prostaglandin/Prostaglandin Analog