Nomenclature
CAS number: 8006-25-5
Ecboline.
Description and references
A mixture of ergocornine, ergocristine, and ergocryptine, q.q.v., with oxytocic
activity. See also the isomeric ergotinine mixture. Prepn:
Barger, Carr, J. Chem. Soc. 91, 337 (1907); Smith, Timmis, ibid. 1930, 1390; Kofler, Arch. Pharm. 275, 455 (1937); Stoll, Hofmann, Helv. Chim. Acta 26, 1570 (1943); Pitra, Sapara, Cesk. Farm. 5, 585 (1956), C.A. 51, 8369f (1957). Toxicity
data: H. Kreitmair, Arch. Exp. Pathol. Pharmakol. 176, 171 (1934).
Properties
Orthorhombic crystals with 2C6H6 from benzene. The solvent of crystn is given up only after
long drying and heating in high vacuum. mp ≈190° (dec) (solvent-free base). [α]D20 -197° (chloroform). Very sol in ethyl and methyl alcohol, acetone,
chloroform, ethyl acetate; slightly sol in ether. Almost insol in
water, petr ether. LD in mice (mg/kg): 0.107 s.c.; 0.032 i.v. (Kreitmair).Derivative
Ergotoxine phosphate.
Properties
Clusters of needles, dec 187°. Sol in 320 parts
water, 15 parts boiling alcohol.Derivative
Ergotoxine ethanesufonate.
Properties
Acicular crystals, dec 209°. Sol in methanol;
slightly in alcohol. Almost insol in water. Solid and solns are
sensitive to light and air.